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Yasuyuki Sakai Selected Research

baysilon (polydimethylsiloxane)

9/2022Scalable Formation of Highly Viable and Functional Hepatocellular Carcinoma Spheroids in an Oxygen-Permeable Microwell Device for Anti-Tumor Drug Evaluation.
11/2020Modular assembly-based approach of loosely packing co-cultured hepatic tissue elements with endothelialization for liver tissue engineering.
1/2014Combination of microwell structures and direct oxygenation enables efficient and size-regulated aggregate formation of an insulin-secreting pancreatic β-cell line.
5/2013Formation and harvesting of thick pancreatic β-cell sheets on a highly O2-permeable plate modified with poly(N-isopropylacrylamide).
4/2010Spontaneous formation of highly functional three-dimensional multilayer from human hepatoma Hep G2 cells cultured on an oxygen-permeable polydimethylsiloxane membrane.

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Yasuyuki Sakai Research Topics

Disease

15Neoplasms (Cancer)
09/2022 - 10/2003
7Hepatocellular Carcinoma (Hepatoma)
09/2022 - 09/2007
6Carcinoma (Carcinomatosis)
08/2016 - 03/2006
4Urinary Bladder Neoplasms (Bladder Cancer)
01/2017 - 10/2003
4Renal Cell Carcinoma (Grawitz Tumor)
07/2013 - 01/2002
3Insulinoma
01/2022 - 05/2013
3Prostatic Neoplasms (Prostate Cancer)
08/2021 - 10/2006
3Type 1 Diabetes Mellitus (Autoimmune Diabetes)
05/2021 - 05/2013
3Hypoxia (Hypoxemia)
01/2019 - 10/2018
3Adenocarcinoma
01/2009 - 02/2004
2Necrosis
09/2022 - 01/2019
2Neoplasm Metastasis (Metastasis)
11/2020 - 01/2014
2Ureteral Obstruction
12/2019 - 10/2016
2Cysts
01/2018 - 02/2004
2Rectal Neoplasms (Rectal Cancer)
09/2017 - 10/2016
2Retroperitoneal Fibrosis
03/2006 - 05/2004
2Liver Failure
01/2005 - 05/2003
1Inflammation (Inflammations)
10/2021
1Drug-Related Side Effects and Adverse Reactions
08/2021
1Proctitis
08/2021
1Colorectal Neoplasms (Colorectal Cancer)
08/2021
1Osteonecrosis (Kienbock's Disease)
07/2021
1Kidney Neoplasms (Kidney Cancer)
07/2021
1Leukemia
04/2021
1Hypersensitivity (Allergy)
04/2021
1Pancreatic Diseases (Pancreatic Disease)
03/2021
1Pathologic Constriction (Stenosis)
12/2019
1Ureteral Neoplasms (Ureteral Cancer)
12/2019
1Paraganglioma (Paragangliomas)
10/2019
1Psoriasis (Pustulosis Palmaris et Plantaris)
09/2019
1Breast Neoplasms (Breast Cancer)
09/2019
1Atopic Dermatitis (Atopic Eczema)
09/2019
1Dermatitis
09/2019
1Shock
08/2019
1Melanoma (Melanoma, Malignant)
07/2019
1Pheochromocytoma
01/2019
1Communicable Diseases (Infectious Diseases)
10/2018
1Urologic Neoplasms (Urological Cancer)
01/2017
1Pancreatic Neoplasms (Pancreatic Cancer)
01/2017
1Lymphatic Metastasis
10/2016

Drug/Important Bio-Agent (IBA)

7Oxygen (Dioxygen)IBA
09/2022 - 04/2010
6Pharmaceutical PreparationsIBA
09/2022 - 01/2005
5baysilon (polydimethylsiloxane)IBA
09/2022 - 04/2010
3pembrolizumabIBA
03/2021 - 11/2020
2poly(lactide) (polylactic acid)IBA
01/2022 - 01/2016
2Histamine (Histamine Dihydrochloride)FDA Link
04/2021 - 09/2019
2Hyaluronic Acid (Hyaluronan)IBA
03/2016 - 09/2010
2Cisplatin (Platino)FDA LinkGeneric
02/2010 - 10/2003
2SteroidsIBA
03/2006 - 05/2004
1Doxorubicin (Adriamycin)FDA LinkGeneric
09/2022
1Insulin (Novolin)FDA Link
01/2022
1angiotensin I (1-7)IBA
10/2021
1Bone Density Conservation AgentsIBA
07/2021
1Neurotransmitter Agents (Neurotransmitter)IBA
04/2021
1CarbonIBA
04/2021
1Bovine Serum AlbuminIBA
04/2021
1AntigensIBA
04/2021
1Calcimycin (A23187)IBA
04/2021
1histamine dehydrogenaseIBA
04/2021
1Calcium IonophoresIBA
04/2021
1Biomarkers (Surrogate Marker)IBA
03/2021
1C-Reactive ProteinIBA
03/2021
1Immune Checkpoint InhibitorsIBA
03/2021
1Therapeutic UsesIBA
01/2021
13-Iodobenzylguanidine (Iobenguane)IBA
10/2019
1Member 1 Subfamily B ATP Binding Cassette TransporterIBA
09/2019
1Proteins (Proteins, Gene)FDA Link
09/2019
1XenobioticsIBA
09/2019
1Uric Acid (Urate)IBA
09/2019
1Serotonin (5 Hydroxytryptamine)IBA
09/2019
1OxazoloneIBA
09/2019
1Indicators and Reagents (Reagents)IBA
09/2019
1Ether (Diethyl Ether)IBA
08/2019
1CysteinyldopaIBA
07/2019
1Melanins (Melanin)IBA
07/2019
1Transcription Factors (Transcription Factor)IBA
01/2019
1HydrogelsIBA
01/2019
1EmulsionsIBA
01/2019
1Nerve Growth Factor (NGF)IBA
01/2019
1Bile Acids and Salts (Bile Acids)IBA
01/2018
1matrigelIBA
01/2018
1PlatinumIBA
01/2017
1CytokinesIBA
01/2017
1Serum AlbuminIBA
10/2016

Therapy/Procedure

7Therapeutics
03/2016 - 05/2004
4Nephroureterectomy
01/2017 - 11/2014
4Nephrectomy
01/2016 - 10/2002
3Radiotherapy
08/2021 - 02/2010
3Transplantation
05/2021 - 09/2010
3Cystectomy
02/2010 - 10/2003
2Stents
12/2019 - 10/2016
2Prostatectomy (Retropubic Prostatectomy)
09/2017 - 10/2009
2Chemoradiotherapy
02/2010 - 10/2003
2Urinary Diversion (Ileal Conduit)
01/2009 - 12/2003
2Laparotomy
10/2002 - 05/2002
1Islets of Langerhans Transplantation
01/2022
1Tooth Extraction (Tooth Extractions)
07/2021
1Electrodes (Electrode)
04/2021
1Microspheres (Microsphere)
10/2018
1Combination Drug Therapy (Combination Chemotherapy)
01/2017